K M Gibson Selected Research

gamma-Aminobutyric Acid (GABA)

1/2019	Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use-limiting visual field defects.
2/2018	Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder.
4/2017	In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding.
1/2017	Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism.
11/2016	Correlation of blood biomarkers with age informs pathomechanisms in succinic semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism.
10/2016	Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism.
12/2009	Visual evoked potentials in succinate semialdehyde dehydrogenase (SSADH) deficiency.
8/2009	Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency.
6/2009	Succinic semialdehyde dehydrogenase deficiency: lessons from mice and men.
12/2008	SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex.

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K M Gibson Research Topics

Disease

28	succinic semialdehyde dehydrogenase deficiency 02/2018 - 03/2001
5	Seizures (Absence Seizure) 12/2008 - 10/2001
4	2-Hydroxyglutaricaciduria 11/2011 - 05/2006
3	Epilepsy (Aura) 01/2017 - 06/2009
3	Intellectual Disability (Idiocy) 06/2009 - 03/2000
2	Toxic Optic Neuropathy 01/2019 - 01/2017
2	Ataxia (Dyssynergia) 06/2009 - 12/2008
2	Mevalonate Kinase Deficiency 11/2007 - 04/2001
2	Absence Epilepsy (Childhood Absence Epilepsy) 11/2004 - 06/2004
2	Status Epilepticus (Complex Partial Status Epilepticus) 11/2004 - 08/2004
1	Necrosis 02/2018
1	Narcolepsy 01/2017
1	Language Development Disorders (Semantic-Pragmatic Disorder) 01/2012
1	Nervous System Diseases (Neurological Disorders) 02/2011
1	Sleep Wake Disorders 06/2009
1	Muscle Hypotonia (Hypotonia) 06/2009
1	isovaleric Acidemia 12/2008
1	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 12/2008
1	Mitochondrial Diseases (Mitochondrial Disease) 03/2007
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 05/2006
1	Metabolic Brain Diseases (Encephalopathy, Metabolic) 01/2005
1	Cognitive Dysfunction 08/2004
1	Ketosis 01/2004
1	Succinyl-CoA:3-oxoacid CoA transferase deficiency 01/2004
1	Gliosis 10/2001
1	Fever (Fevers) 04/2001
1	Dystonia (Limb Dystonia) 03/2001
1	Methylmalonate Semialdehyde Dehydrogenase Deficiency 07/2000
1	Methylmalonic acidemia 07/2000
1	2-Methylbutyryl-CoA Dehydrogenase Deficiency 06/2000
1	Autolysis 03/2000
1	Smith-Lemli-Opitz Syndrome 03/2000
1	Fetal Death 03/2000
1	Osteopetrosis 02/2000

Drug/Important Bio-Agent (IBA)

21	gamma-Aminobutyric Acid (GABA)IBA 01/2019 - 10/2001
16	Succinate-Semialdehyde Dehydrogenase (Succinic Semialdehyde Dehydrogenase)IBA 04/2017 - 10/2001
9	AcidsIBA 01/2019 - 07/2000
8	EnzymesIBA 11/2011 - 03/2000
6	4-hydroxybutyric acidIBA 01/2012 - 08/2004
3	Vigabatrin FDA Link 01/2019 - 01/2012
3	Ketoglutaric Acids (Ketoglutaric Acid)IBA 11/2011 - 05/2006
3	Oxidoreductases (Dehydrogenase)IBA 12/2009 - 07/2000
2	Biomarkers (Surrogate Marker)IBA 01/2017 - 11/2016
2	Sodium Oxybate (gamma Hydroxybutyrate)FDA Link 01/2017 - 12/2007
2	Pharmaceutical PreparationsIBA 01/2017 - 01/2000
2	Biological ProductsIBA 01/2012 - 01/2000
2	Glutamine (L-Glutamine)FDA Link 12/2007 - 08/2004
2	Glutamic Acid (Glutamate)FDA Link 12/2007 - 08/2004
2	mevalonate kinaseIBA 11/2007 - 04/2001
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2019
1	4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)IBA 01/2019
1	LigandsIBA 02/2018
1	Oxygen (Dioxygen)IBA 02/2018
1	Adenosine Triphosphate (ATP)IBA 02/2018
1	Superoxides (Superoxide)IBA 02/2018
1	NCS 382IBA 02/2018
1	Neurotransmitter Agents (Neurotransmitter)IBA 04/2017
1	Aldehyde DehydrogenaseIBA 01/2017
1	Sirolimus (Rapamycin)FDA Link 01/2017
1	Aminobutyrates (Aminobutyric Acid)IBA 11/2016
1	GlutaratesIBA 11/2011
1	isocitric acid (isocitrate)IBA 11/2011
1	alpha-hydroxyglutarateIBA 11/2011
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 11/2011
1	IsotopesIBA 11/2011
1	GABA-A Receptors (GABA(A) Receptor)IBA 08/2009
1	Flumazenil (Romazicon)FDA LinkGeneric 08/2009
1	Fatty Acids (Saturated Fatty Acids)IBA 12/2008
1	AntioxidantsIBA 10/2007
1	Glutathione (Reduced Glutathione)IBA 03/2007
1	hydroxyacid-oxoacid transhydrogenaseIBA 05/2006
1	Succinic Acid (Succinate)IBA 01/2005
1	succinic semialdehydeIBA 01/2005
1	dinitrophenylhydrazineIBA 01/2005
1	CGP 35348IBA 11/2004
1	Ethosuximide (Zarontin)FDA LinkGeneric 11/2004
1	Explosive Agents (Explosives)IBA 11/2004
1	Alanine (L-Alanine)FDA Link 08/2004
1	Amino Acids FDA Link 08/2004
1	Arginine (L-Arginine)FDA Link 08/2004
1	Aspartic Acid (Aspartate)FDA Link 08/2004
1	CystathionineIBA 08/2004
1	Methionine (L-Methionine)FDA Link 08/2004
1	Serine (L-Serine)FDA Link 08/2004
1	Taurine FDA Link 08/2004
1	homocarnosineIBA 08/2004
1	succinyl-coenzyme A (succinyl-CoA)IBA 01/2004
1	KetonesIBA 01/2004
1	TransferasesIBA 01/2004
1	Beta ketothiolase deficiencyIBA 03/2001
1	DNA (Deoxyribonucleic Acid)IBA 03/2001
1	beta-AlanineIBA 07/2000
1	hydracrylic acidIBA 07/2000
1	Isoleucine (L-Isoleucine)FDA Link 06/2000
1	7-dehydrocholesterolIBA 03/2000
1	CholesterolIBA 03/2000
1	SterolsIBA 03/2000
1	ChondroitinIBA 02/2000

Therapy/Procedure

1	Therapeutics 01/2017
1	Catheters 02/2011